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Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of Zimulti (rimonabant) to the US FDA for use in obese and overweight patients with associated risks factors because of continuing concerns about increased risks for suicidal thoughts among some users. Those trials compared taking rimonabant (20 milligrams a day) against a placebo. "If one is using rimonabant, patients should be monitored carefully for the emergence of depressive symptoms and/or suicidal thoughts," he added. 25 percent increase in percent atheroma volume (PAV) in those taking rimonabant, compared to 0. Food and Drug Administration panel recommended that rimonabant should not be given the FDA's blessing because of continuing concerns about increased risks for suicidal thoughts among some users. Rimonabant is not yet accustomed for use in the United States, area it is accepted as Zimulti.

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